Study of oxytocin receptor in human myometrium using highly specific 3H-labeled oxytocin.
نویسندگان
چکیده
منابع مشابه
Desensitization of oxytocin receptors in human myometrium.
In the present study, we investigated the possible mechanisms by which oxytocin might regulate oxytocin receptor (OTR) density. Exposure of cultured myometrial cells to oxytocin for a prolonged period caused desensitization: the steady-state level of oxytocin binding was 210 x 10(3) binding sites/cell, but this was time-dependently reduced to 20.1 x 10(3) sites/cell by exposing the cells to oxy...
متن کاملDifferential Effects of Oxytocin Receptor Antagonists, Atosiban and Nolasiban, on Oxytocin Receptor–Mediated Signaling in Human Amnion and Myometrium
One of the most established roles of oxytocin (OT) is in inducing uterine contractions and labor. Apart from inducing contractions, our recent studies showed that OT can also activate proinflammatory pathways in both human myometrial and amnion cells, which suggests that the proinflammatory role of OT should be taken into account when developing tocolytics targeting the OT/oxytocin receptor (OT...
متن کاملOxytocin pretreatment attenuates oxytocin-induced contractions in human myometrium in vitro.
BACKGROUND Oxytocin receptor desensitization has been shown to occur in humans at biomolecular level and in isolated rat myometrium; however, its effect on human myometrial contractility has not been demonstrated. The objective of this in vitro study was to investigate the contractile response of human pregnant myometrium to oxytocin after pretreatment with different concentrations of oxytocin ...
متن کاملOxytocin receptor gene expression of estrogen-stimulated human myometrium in extracorporeally perfused non-pregnant uteri.
Oxytocin (OT) and the oxytocin receptor (OTR) seem to be less important for uterine contractility-associated disorders of the non-pregnant uterus compared to the pregnant uterus. In the present study, we investigated the mutual dependence of OTR, OT and 17beta-estradiol (E(2)) with regard to the localization of OTR in the non-pregnant uterus. Utilizing our established model for extracorporeal p...
متن کاملPreparation and Biodistribution of [67Ga]-labeled- oxytocin for SPECT purposes
Background: Oxytocin (OT) is a paracrine hormone with various biological activities and many sex organs in both sexes, as well as many tumor cells have shown to have related receptors. In this study the development of a receptor imaging tracer for possible tumor imaging has been described. Materials and Methods: OT was successively labeled with [67Ga]-gallium chloride after conjugation with fre...
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ژورنال
عنوان ژورنال: Endocrinologia Japonica
سال: 1979
ISSN: 0013-7219,2185-6370
DOI: 10.1507/endocrj1954.26.515